LI Hui
Degree：Ph.D.
Title：Professor, Doctoral Supervisor
Address： Room 9911, Jingshi Building, Beijing Normal University
ZIP code： 100875
Telephone： +86 10 58807880
Email：huili@bnu.edu.cn; huili@iphy.ac.cn
Homepage：
2006-2012 Ph.D. in Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences
2003-2006 Bachelor, Shandong University
2020- Visiting Professor, Institute of Physics, Chinese Academy of Sciences
2019- Professor, School of Systems Science, Beijing Normal University
2017-2018 Visiting Scholar, Harvard University
2015.9-12 Visiting Scholar, Oxford University
2015-2019 Associate Professor, Institute of Physics, Chinese Academy of Sciences
2012-2015 Assistant Professor, Institute of Physics, Chinese Academy of Sciences
Research Interests：
Dr. Li’s biophysical research focuses on the dynamics of living systems, across the molecules, cells and multi-cellular tissue levels, to understand their biological functions and relevant human diseases behind the complexly dynamical behaviors. So far, he has published more than 50 papers including Nature Physics, Nature Communications, PNAS, Adv. Sci., JACS, Angewandte Chemie, ACS Nano, Small, etc. For details please see ORCID: https://orcid.org/0000-0003-0551-9912 .
Areas of Research: 1) Dynamics of living systems; 2) Cell biophysics; 3) Single-molecule imaging.
Publication List (Secleted)：
1. Wei, T., Yang, X., Jiang, C., Liao, K., Ye, H., Luo, H. Y., Liu, Y. R., Wang, P. Y., Meng, F., Dou, S. X.*, Rong, Z.* & Li, H.* Osmotic pressure regulates DNA labelling and transcription with dCas9-SunTag system in live cells. Nature Communications 17, 773 (2026).
2. Liu, F., Gao, B., Lei, L. R., Liu, S. N., Li, H.* & Guo, M.* Intercellular flow dominates the poroelasticity of multicellular tissues. Nature Physics 21, 1311-1318 (2025).
3. Wang, H. C.; Zheng, Y. T.; Zhang, J. H.; Gao, Y. L.; Chen, J. J.; Cai, P. W.; Wang, J. Y.; van Esch, J. H.; Guo, X. H.; Li, H.*; Wang, Y. M.* Synthesis of Abiotic Supramolecular Polymers Inside Living Cells via Organocatalysis-Mediated Self-Assembly. Angew Chem Int Edit, 64, e202500998 (2025). (Hot Paper)
4. Wei, T., Luo, H. Y., Jiang, C., Wang, P. Y., Dou, S. X.* & Li, H.* Mechanically Regulated Biphasic Chromatin Dynamics during Cellular Necrosis. J Phys Chem Lett 16, 12005-12009 (2025). (Front Cover)
5. Zhang, M. L., Zhang, Z., Niu, X. Z., Ti, H. Y., Zhou, Y. X., Gao, B., Li, Y., Liu, J. L., Chen, X.* & Li, H.* Interplay Between Intracellular Transport Dynamics and Liquid‒Liquid Phase Separation. Advanced Science 11, e2308338 (2024). (Front Cover)
6. Liu, J., Wang, Y., Gao, B., Zhang, K., Li, H.*, Ren, J., Huo, F., Zhao, B., Zhang, L., Zhang, S.* & He, H.* Ionic Liquid Gating Induces Anomalous Permeation through Membrane Channel Proteins. Journal of the American Chemical Society 146, 13588-13597 (2024).
7. Luo, H. Y., Jiang, C., Dou, S. X., Wang, P. Y.* & Li, H.* Quantum Dot-Based Three-Dimensional Single-Particle Tracking Characterizes the Evolution of Spatiotemporal Heterogeneity in Necrotic Cells. Analytical Chemistry 96, 11682-11689 (2024). (Front Cover)
8. Jiang, C., Luo, H. Y., Xu, X., Dou, S. X., Li, W., Guan, D., Ye, F., Chen, X., Guo, M., Wang, P. Y.* & Li, H.* Switch of cell migration modes orchestrated by changes of three-dimensional lamellipodium structure and intracellular diffusion. Nature Communications 14, 5166 (2023).
9. Yuan, J. W., Zhang, Y. N., Liu, Y. R., Li, W., Dou, S. X., Wei, Y., Wang, P. Y.* & Li, H.* Diffusion Behaviors of Integrins in Single Cells Altered by Epithelial to Mesenchymal Transition. Small 18, e2106498 (2022). (Back Cover)
10. Jiang, C., Dou, S. X., Wang, P. Y.*& Li, H.* Quantifying transport dynamics with three-dimensional single-particle tracking in adherent cells. STAR Protoc 3, 101790 (2022).
11. Liu, F.* Yang, Z., Yao, R., Li, H.*, Cheng, J.*& Guo, M.* Bulk Electroporation for Intracellular Delivery Directly Driven by Mechanical Stimulus. ACS Nano 16, 19363-19372 (2022).
12. Li, H.*, Zheng, Y., Han, Y. L., Cai, S. Q.*& Guo, M.*Nonlinear elasticity of biological basement membrane revealed by rapid inflation and deflation. Proceedings of the National Academy of Sciences of the United States of America 118 (2021).
13. Jiang, C., Li, B., Dou, S. X., Wang, P. Y.*& Li, H.* Quasi-Two-Dimensional Diffusion in Adherent Cells Revealed by Three-Dimensional Single Quantum Dot Tracking. Chinese Physics Letters (Express Letters) 37, 078701 (2020).
14. Li, B., Dou, S. X., Yuan, J. W., Liu, Y. R., Li, W., Ye, F. F., Wang, P. Y. & Li, H.* Intracellular transport is accelerated in early apoptotic cells. Proceedings of the National Academy of Sciences of the United States of America 115, 12118-12123 (2018).
15. Li, H., Dou, S. X., Liu, Y. R., Li, W., Xie, P., Wang, W. C. & Wang, P. Y.* Mapping intracellular diffusion distribution using single quantum dot tracking: compartmentalized diffusion defined by endoplasmic reticulum. Journal of the American Chemical Society 137, 436-444 (2015).