LI Hui
Degree：Ph.D.
Title：Professor, Doctoral Supervisor
Address： Room 9911, Jingshi Building, Beijing Normal University
ZIP code： 100875
Telephone： +86 10 58807880
Email：huili@bnu.edu.cn; huili@iphy.ac.cn
Homepage：
2006-2012 Ph.D. in Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences
2003-2006 Bachelor, Shandong University
2020- Visiting Professor, Institute of Physics, Chinese Academy of Sciences
2019- Professor, School of Systems Science, Beijing Normal University
2017-2018 Visiting Scholar, Harvard University
2015.9-12 Visiting Scholar, Oxford University
2015-2019 Associate Professor, Institute of Physics, Chinese Academy of Sciences
2012-2015 Assistant Professor, Institute of Physics, Chinese Academy of Sciences
Research Interests：
Dr. Li’s biophysical research focuses on the dynamics of living systems, across the molecules, cells and multi-cellular tissue levels, to understand their biological functions and relevant human diseases behind the complexly dynamical behaviors. So far, he has published more than 30 papers including PNAS, Nat Commun, J. Am. Chem. Soc., Adv. Sci., etc. For details please see ORCID: https://orcid.org/0000-0003-0551-9912 .
Areas of Research: 1) Dynamics of living systems; 2) Cell biophysics; 3) Single-molecule imaging.
Publication List (Secleted)：
1. Zhang, M. L.; Zhang, Z.; Niu, X. Z.; Ti, H. Y.; Zhou, Y. X.; Gao, B.; Li, Y.; Liu, J. L.; Chen, X.*; Li, H.* Interplay Between Intracellular Transport Dynamics and Liquid‒Liquid Phase Separation. Adv Sci 2024, 11 (19), e2308338. (Front Cover)
2. Liu, J.; Wang, Y.; Gao, B.; Zhang, K.; Li, H.*; Ren, J.; Huo, F.; Zhao, B.; Zhang, L.; Zhang, S.*; He, H.* Ionic Liquid Gating Induces Anomalous Permeation through Membrane Channel Proteins. J. Am. Chem. Soc. 2024, 146 (19), 13588-13597.
3. Luo, H. Y.; Jiang, C.; Dou, S. X.; Wang, P. Y.*; Li, H.* Quantum Dot-Based Three-Dimensional Single-Particle Tracking Characterizes the Evolution of Spatiotemporal Heterogeneity in Necrotic Cells. Anal. Chem. 2024. (Cover)
4. Jiang, C.; Luo, H. Y.; Xu, X.; Dou, S. X.; Li, W.; Guan, D.; Ye, F.; Chen, X.; Guo, M.; Wang, P. Y.*; Li, H.* Switch of cell migration modes orchestrated by changes of three-dimensional lamellipodium structure and intracellular diffusion. Nat Commun 2023, 14 (1), 5166.
5. Kong, J.-W.; Dou, S.-X.; Li, W.*; Li, H.*.; Wang, P.-Y.* Parallel DNA G-Quadruplex Induced and Stabilized by Curaxin CBL0137. Chinese Phys Lett 2023, 40 (7).
6. Yuan, J. W.; Zhang, Y. N.; Liu, Y. R.; Li, W.; Dou, S. X.; Wei, Y.*; Wang, P. Y.*; Li, H.* Diffusion Behaviors of Integrins in Single Cells Altered by Epithelial to Mesenchymal Transition. Small 2022, 18 (5), e2106498. (Back Cover)
7. Jiang, C.; Yang, M.; Li, W.; Dou, S. X.; Wang, P. Y.*; Li, H.* Spatiotemporal three-dimensional transport dynamics of endocytic cargos and their physical regulations in cells. iScience 2022, 25 (5), 104210.
8. Liu, F.*; Yang, Z.; Yao, R.; Li, H.*; Cheng, J.*; Guo, M.* Bulk Electroporation for Intracellular Delivery Directly Driven by Mechanical Stimulus. ACS Nano 2022, 16 (11), 19363-19372.
9. Jiang, C.; Dou, S. X.; Wang, P. Y.*; Li, H.* Quantifying transport dynamics with three-dimensional single-particle tracking in adherent cells. STAR Protocols 2022, 3 (4), 101790.
10. Zhang, M. L.; Ti, H. Y.; Wang, P. Y.*; Li, H.* Intracellular transport dynamics revealed by single-particle tracking. Biophys Rep 2021, 7 (5), 413-427.
11. Li, H.*#; Zheng, Y.#; Han, Y. L.; Cai, S. Q.*; Guo, M.* Nonlinear elasticity of biological basement membrane revealed by rapid inflation and deflation. Proc. Natl. Acad. Sci. U. S. A. 2021, 118 (11).
12. Jiang, C.; Li, B.; Dou, S. X.; Wang, P. Y.*; Li, H.* Quasi-Two-Dimensional Diffusion in Adherent Cells Revealed by Three-Dimensional Single Quantum Dot Tracking. Chinese Phys Lett (Express Letters) 2020, 37 (7).
13. Li, H.; Ye, F.; Ren, J. Y.; Wang, P. Y.; Du, L. L.; Liu, J. L.* Active transport of cytoophidia in Schizosaccharomyces pombe. FASEB J. 2018, 32 (11), 5891-5898.
14. Li, B.; Dou, S. X.; Yuan, J. W.; Liu, Y. R.; Li, W.; Ye, F. F.; Wang, P. Y.; Li, H.* Intracellular transport is accelerated in early apoptotic cells. Proc. Natl. Acad. Sci. U. S. A. 2018, 115 (48), 12118-12123.
15. Lu, X. M.; Li, H.*; You, J.; Li, W.; Wang, P. Y.; Li, M.; Dou, S. X.*; Xi, X. G. Folding Dynamics of Parallel and Antiparallel G-Triplexes under the Influence of Proximal DNA. J Phys Chem B 2018, 122 (41), 9499-9506. (Cover)
16. Li, H.; Dou, S. X.; Liu, Y. R.; Li, W.; Xie, P.; Wang, W. C.; Wang, P. Y.* Mapping intracellular diffusion distribution using single quantum dot tracking: compartmentalized diffusion defined by endoplasmic reticulum. J. Am. Chem. Soc. 2015, 137 (1), 436-444.